TCC: an R package for comparing tag count data with robust normalization strategies
نویسندگان
چکیده
منابع مشابه
Package 'tcc' Title Tcc: Differential Expression Analysis for Tag Count Data with Robust Normalization Strategies
April 26, 2017 Type Package Title TCC: Differential expression analysis for tag count data with robust normalization strategies Version 1.16.0 Author Jianqiang Sun, Tomoaki Nishiyama, Kentaro Shimizu, and Koji Kadota Maintainer Jianqiang Sun , Tomoaki Nishiyama Description This package provides a series of functions for performing dif...
متن کاملTCC: Differential expression analysis for tag count data with robust normalization strategies
The R/Bioconductor package, TCC, provides users with a robust and accurate framework to perform differential expression (DE) analysis of tag count data. We recently developed a multi-step normalization method (TbT; Kadota et al., 2012 [3]) for two-group RNA-seq data. The strategy (called DEGES) is to remove data that are potential differentially expressed genes (DEGs) before performing the data...
متن کاملTitle Tcc: Differential Expression Analysis for Tag Count Data with Robust Normalization Strategies
December 22, 2016 Type Package Title TCC: Differential expression analysis for tag count data with robust normalization strategies Version 1.14.0 Author Jianqiang Sun, Tomoaki Nishiyama, Kentaro Shimizu, and Koji Kadota Maintainer Jianqiang Sun , Tomoaki Nishiyama Description This package provides a series of functions for performing ...
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MOTIVATION The careful normalization of array-based comparative genomic hybridization (aCGH) data is of critical importance for the accurate detection of copy number changes. The difference in labelling affinity between the two fluorophores used in aCGH-usually Cy5 and Cy3-can be observed as a bias within the intensity distributions. If left unchecked, this bias is likely to skew data interpret...
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Normalization is the first critical step in microbiome sequencing data analysis used to account for variable library sizes. Current RNA-Seq based normalization methods that have been adapted for microbiome data fail to consider the unique characteristics of microbiome data, which contain a vast number of zeros due to the physical absence or under-sampling of the microbes. Normalization methods ...
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ژورنال
عنوان ژورنال: BMC Bioinformatics
سال: 2013
ISSN: 1471-2105
DOI: 10.1186/1471-2105-14-219